Frequently Asked Questions

General Questions about Protandim

Protandim is the only supplement clinically proven (in a peer-reviewed, human clinical study) to reduce oxidative stress in humans by an average of 40 percent in 30 days.

Protandim is protected by U.S. patents and is the subject of a number of peer-reviewed clinical studies.

This patented antioxidant therapy is many times more powerful than red wine, oranges, blueberries, juices or other popular antioxidant supplements.

Protandim works by increasing the body’s natural antioxidant protection at the cellular level by inducing the protein Nrf2 to trigger cells to produce naturally occurring protective antioxidant enzymes such as superoxide dismutase (SOD), catalase and the enzymes involved in glutathione synthesis and metabolism.

Nationally recognized anti-aging expert Dr. Joe McCord, the scientist behind Protandim, explains,

“Researchers and scientists agree that aging is the result of cellular deterioration caused by free radicals, which are rogue molecules.

It is impossible to avoid free radicals because the food you eat and the air you breathe, as well as stress or even vigorous exercise, can stimulate cells to produce destructive free radicals in staggering numbers.

With each year, a person’s body becomes less effective at fighting free radicals.

A person’s body fights free radicals by producing its own antioxidant enzymes. But as we grow older, our bodies produce more free radicals and fewer of these antioxidant enzymes to fight the battle of aging.

That’s where Protandim plays a critical role.

Protandim boosts the body’s own production of antioxidant enzymes at the cellular level with enough neutralizing capacity to eliminate the age-related increase in free radical damage.”

Protandim is different from other antioxidant supplements in the way it works.

Instead of providing the body with additional dietary antioxidants and ‘supplementing’ the body, (regular supplements fall into this category and are commonly called consumable or “direct” antioxidants), Protandim works from within your body, to help fight free radicals and protect against oxidative stress.

This is why Protandim is different than any other antioxidant on the market today; your body is actually producing the antioxidant power.

You make antioxidants rather than take them!

Protandim contains 1.8 mg of caffeine per tablet. (By comparison, a Starbuck’s coffee may contain up to 150 mg. and “caffeine free” coffee may typically contain between 4-7 mg).

Protandim UK contains Turmeric, Green Tea, Black Pepper, Bacopa and Milk Thistle. The ingredients are a slight variation than the US as Aswaganda is not permitted in the UK. However, the actual output of the product and how the NRF2 works is exactly the same.

Protandim’s actions result from its ability to activate the transcription factor known as Nrf2. Protandim contains five ingredients that are known to scientists as Nrf2 activators. Nrf2 is a protein messenger contained in every cell of the body that sends information to the cell’s DNA.

When Nrf2 is activated, it enters the nucleus and it turns on several hundred of these 25,000 genes. And the genes that it turns on, or turns up, are known collectively as “survival genes.” What is a survival gene? These genes enable cells to survive in the face of several different kinds of stress, especially oxidative stress, which occurs when free radicals and other oxidants overwhelm the body’s natural antioxidant enzymes.

So, Protandim, as a Nrf2 activator, activates survival genes, such as antioxidant genes that keep us safe from free radicals and oxidants.

Protandim is among the very first of the products that are appearing, and will appear, as Nrf2 activators.

Many people mistakenly believe their antioxidant needs are fulfilled by eating blueberries, drinking expensive “miracle juices” and applying antioxidant facial creams.

What they don’t realize is that their daily antioxidant needs cannot be fulfilled by consuming any amount of blueberries, dark chocolate or red wine.

Effective antioxidant protection absolutely requires adequate production of the body’s own antioxidant enzymes.

Protandim contains a compound based upon six United States’ patents, 1 Australia patent, 1 China  patent and has been proven to protect against oxidative stress.

No, the blend of ingredients and their special formulation is unique to Protandim and is the subject of six US patents, one Australian patent, and one Chinese patent.

The combination of ingredients creates a synergy that has been studied and different than traditional antioxidants.

Protandim is 18 times more powerful than the sum of the ingredients together.

Yes, absolutely. The raw materials are tested for: pesticides/herbicides, heavy metals, active compound in Protandim’s five active ingredients (for example, we test bacopa for bacosides and Turmeric for Curcumonoids), all microbial tests and efficacy/bioavailability.

Yes, the raw ingredients are pressed into tablet form. Our tablets are pressed without any extraneous heat.

The only heat that results from the process is from natural friction. There is no raw material degradation from the process.

This is considered “cold” pressed or “soft” pressed.

Yes, we meet or exceed the Current Good Manufacturing Practices (“cGMPs”) for Nutritional Supplements.

All raw materials are validated before they are purchased. This means we test all inbound raw materials for quality and purity.

Also, Protandim is subject to existing dietary supplement laws, such as the Dietary Supplement Health and Education Act, including adverse event reporting requirements.

LifeVantage has established the safety and purity of all its ingredients through independent laboratory testing.

Protandim Safety

No, Protandim does not contain any banned or controlled substances.  Every lot of Protandim is analyzed and certified by the Banned Substances Control Group (BSCG) to assure that Protandim does not contain any banned or controlled substances.

It’s best to take Protandim with food.

Some of the active ingredients in Protandim are fat soluble.

Although it is not absolutely necessary, taking Protandim with a meal containing some fat allows the ingredients to be absorbed more efficiently.

The shelf life for Protandim is three years.

No, there is no known mechanism whereby Protandim loses effectiveness over time.

The formula has not been changed and bioactivity is monitored to maintain consistent potency with regard to the activation of the Nrf2 transcription factor–the mechanism by which Protandim works.

No, the ability to absorb the ingredients is self-limiting, so after a certain point no more is absorbed.

Some Western diets are lacking in certain nutritional elements, so multivitamin supplementation may be beneficial for some people.

You can discontinue supplementing with antioxidants, however, because Protandim is more effective at eliminating free radical damage than supplementation with conventional antioxidants.

We do not expect there to be any side effects for the typical Protandim consumer.

However, some individuals may have natural allergic responses to one or more of the ingredients, just as some people are allergic to pollen or penicillin.

These allergic responses to Protandim generally appear as gastrointestinal disturbances (i.e., stomach ache, diarrhea, vomiting) or sometimes as a headache or rash on the hands or feet.

The symptoms typically disappear if Protandim is discontinued.

If you are experiencing any adverse reaction, discontinue use of the product and please get in touch.


TrueScience anti-aging cream has enhanced Nrf2 technology.

The enhanced Nrf2 technology blend comprises of 5 original ingredients found in global Protandim and in the first cream namely, bacopa, milk thistle, turmeric, green tea and black pepper plus cabbage (brassica) and plantain (Plantago) extracts.

This overall combination helps to protect the skin from oxidative stress.

It helps you skin make its own collagen and elastin and it contains no parabens at all.

The cleanser is currently undergoing some changes so that it meets with UK / European regulations.

Step 2 Perfecting Lotion

DIRECTIONS: Begin with clean, dry skin. Pour 1 teaspoon into the palm of your hand. Evenly distribute onto the palms of hands by patting. Smooth the product gently onto the skin of your face sweeping backwards towards your hairline then apply to neck and décolleté. If you wish you may apply to arms, legs or back of hands to help diminish the appearance of discoloration. Let it air-dry. Your skin will feel smooth and silky. Use AM and PM for best results. You may feel a slight tingling or tightening upon application. This is normal for this potent formula and should not last more than a few seconds.

FOR MEN AFTER SHAVING: Begin with clean, shaven and dry skin. Smooth the product gently onto the skin of your face after shaving for a cool and refreshing feel. Soothes irritated skin and helps diminish redness. Rebalances skin’s natural protective barrier.

Step 3 Eye Corrector Serum

DIRECTIONS: This is a potent eye serum so please use 1 pump per application. (One application equals two eyes.) Apply to clean skin. Pump once to dispense onto the back of your hand. Using your ring finger gently tap the serum around both eyes using a circular motion. Apply first under the eyes and lower eyelids. Next apply to crow’s feet, smoothing the product backwards towards your hairline. Lastly, apply to your upper eyelids. Use AM and PM for best results. You may feel a slight tingling, warming or burning sensation upon initial applications. This sensation should subside after a few minutes. If the sensation persists beyond a few minutes after the second or third application, reduce the amount used or discontinue.

Step 4 Anti-Aging Cream

DIRECTIONS: Apply to clean skin. Dispense 3 pumps of the cream into the palm of your hand. Approximately the size of a large pea. Apply with your fingertips all over the face, neck and décolleté. Smooth the cream backwards towards your hairline. Pay special attention to the area in front of your ears. Wait 1-3 minutes before applying sunscreen or make-up. Use AM and PM for best results. You may feel a slight tingling, warming or burning sensation upon application. This is normal for this potent formula and should not last more than a few seconds. If the sensation persists, reduce the amount.

The TrueScience regimen offers a difference you can truly see and feel because the benefits of each product are additive to one another.

The more products used together, the better the results. Each product targets a different trouble spot.

TrueScience Perfecting Lotion is a new category all its own. It is not a toner. It is not a serum.

It is hybrid lotion that is light to apply while leaving the skin feeling smooth and hydrated.

It also features LifeVantage’s proprietary enhanced Nrf2 technologies to help your skin protect itself from free radical damage.

Used every day, Perfecting Lotion works to improve skin clarity and even tone.

First, it’s a serum, while many eye products are creams.

Second, TrueScience Eye Corrector Serum is specifically formulated to work on the fragile skin around the eyes.

It helps minimize the appearance of dark circles under the eyes. It also features LifeVantage’s proprietary Nrf2 technology to help your skin protect itself from free radical damage.

Individual results will vary.

The regimen has been independently tested and shown to be efficacious for reducing the signs of aging (fine lines, wrinkles, skin discoloration, elasticity) when used twice a day for at least 28 days.

Our skincare line contains exclusive formula ingredients available only to LifeVantage. Our skincare line is the only line of products in the Direct Selling industry using the nrf2 technology.

Also, many competitor’s clinical studies are conducted on individual ingredient within their product. LifeVantage’s clinical study was conducted on the finished product.

The results of our study showed a very high approval rate of users.

Ninety-three percent of participants agreed that they would recommend this product.*

*As part of an eight week clinical study, participants were asked to complete a self-assessment survey based on their use of the TrueScience products.  Individual results may vary.